The 40-year-old comedian and TV presenter’s call comes as the town gears up to host the Transplant Games in August.
Paddy, a keen motorcyclist, said it was vital people understood the importance of signing up.
“Anything that saves lives can only be a good thing, so I would urge as many people as possible to register,” he said while visiting the USN Bolton Arena, where he is a gym member.
There are more than 60 people in the town who rely on drugs and medical intervention to keep them alive until a suitable organ match can be found.
And there are currently more than 67,000 people from Bolton on the register — but we want thousands more to sign up.
The campaign, which has been backed by top doctors and political leaders in the town, has been launched ahead of Westfield Health British Transplant Games which are due to take place in Bolton in August.
The games have been held annually since 1978 and will go ahead at various locations throughout Bolt-on.
Team members will be competing in sports like swimming, running, archery, golf and fishing.
The event is designed to raise awareness of the benefits of transplants and the importance of people signing up to become new donors.
Have you been saved by an organ donation or are you on the list waiting for a donation? Contact The Bolton News on 01204 537270 or firstname.lastname@example.org