A 25-year-old man is undergoing surgery after he stabbed himself in the neck.
An ambulance was called and the man was rushed to Manchester Royal Infirmary, where he is receiving treatment.
The house has now been boarded up following the incident.
A neighbour, who asked not to be named, said around 10 police cars came to the street at 3.30am, and they had broken into the house.
He said: "There was shouting and a female crying outside the property with what sounded like glass breaking."
Police said they are investigating the incident.