FC United fought back from 3-1 down to level the scores, but they still succumbed to defeat in Merseyside.
Karl O’Donnell put the home side into a half-time lead, before Liam Kennedy doubled Prescot’s advantage on 50 minutes.
Kyle Wilson pulled one back for the rebels, but Prescot went straight up the other end and scored again – this time through skipper Eddie Taylor.
FC manager Karl Marginson made a triple substitution and threw caution to the wind by switching to a 3-4-3 formation, and it paid almost instant dividends.
Chris Baguley reduced the arrears before Kyle Wilson’s penalty levelled the scores.
However, the visitors were not able to shut up shop and Karl Connelly’s stunning finish into the top corner gave Prescot the points.
FC did have a chance to equalise with the last kick off the game, but Wilson saw his volley hit the bar.
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