Wanderers make two changes from the side that last played at White Hart Lane 10 days ago, bringing Mark Davies and Chris Eagles into their starting line-up.
With Fabrice Muamba making continued progress in the nearby London Chest Hospital, and receiving text updates throughout, there is already a more joyous
feeling around the stadium than might have been expected.
Wanderers came close to pulling out of the competition altogether. They line up tonight with emotions still fresh, but also knowing a semi-final place at Wembley against Chelsea is tantalisingly
Martin Petrov drops to the bench after his impressive performance against Blackburn, with Eagles likely to start on the right and Ryo Miyaichi from the left.
Spurs make three changes from a week last Saturday, with Emmanuel Adebayor, Jake Livermore and Ledley King replacing Michael Dawson, Jermain Defoe and Younes Kaboul.
Tottenham: Cudicini, Walker, King, Nelsen, Assou-Ekotto, Modric, Livermore, Parker, Bale, Adebayor, Van der Vaart.
Subs: Friedel, Kaboul, Saha, Giovani, Defoe, Kranjcar, Rose.
Bolton: Bogdan, Alonso, Boyata, Knight, Ricketts, Reo-Coker, Mark Davies, Pratley, Eagles, Klasnic, Miyaichi.
Subs: Jaaskelainen, Sanli, Petrov, Kevin Davies, Ngog, Ream, Vela.
Referee: Howard Webb (S Yorkshire)