England wing Jack Nowell will undergo surgery next month to solve a persistent knee problem, ruling him out of the summer tour to New Zealand.
The 20-year-old Exeter wing has not played since damaging nerves in his shoulder in the Devon club's 45-15 Aviva Premiership defeat at Leicester Tigers on March 23.
Exeter bosses have opted to combine Nowell's enforced rest due to shoulder trouble with scheduled surgery to clear up his knee problem.
Nowell broke into Stuart Lancaster's England set-up during the RBS 6 Nations, but his summer absence could pave the way for in-form Saracen Chris Ashton's recall.
England face New Zealand in Auckland, Dunedin and Hamilton in a three-Test series in June, a clear marker of their Rugby World Cup 2015 preparations.
"Jack has a pretty bad shoulder injury," Exeter boss Rob Baxter told the Daily Mail.
"It was going to be hit and miss to get him back in time for the end of the season and he also needs an operation on a long-term knee issue.
"This is an important chance to get on top of that situation; he's had the knee injury for pretty much all of his senior career."
Nowell has won all of his five caps in this campaign's Six Nations, benefiting from injuries to Marland Yarde and Christian Wade to claim senior honours.
Saracens flyer Ashton has not featured in 2014 after being jettisoned by head coach Lancaster, but his recent fine form could now command a summer recall.
Ashton claimed two tries in Saracens' 46-6 Heineken Cup semi-final demolition of Clermont, to set a new single-season try record of 11 for the European competition.