Vandals smashed the windows of a number of cars parked in the Sharples area.
The windows of at least six cars parked on Florence Avenue, Douglas Street, Kellett Street, Murton Terrace and Ollerton Street have been smashed.
No attempt was made to steal the cars or any items from inside.
The vandalism happened on three consecutive nights from January 23 until January 25, and the total damage will cost up to £2,000 to repair.
PC Graham Neil, Community Beat Manager for Astley Bridge and Sharples, said: "These acts of criminal damage are not only causing distress to residents but also a great deal of expense.
"I would appeal to anyone who has information, or any witnesses, to contact police on 0161 856 5761 or Crimestoppers, in confidence, on 0800 555 111."
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