Diversions are in place at Junction 32 (Broughton) and 31 (Samlesbury) and the carraigeway has been shut all morning.
Access to the M6 from the M55 southbound is also restricted but the link road from the M55 to the M6 north carriageway is open.
In an update released at midday the Lancashire police said: "We were called at around 4.15am to reports a car had crashed on the slip road at junction 31. No other vehicles are thought to have been involved.
"The driver of the vehicle was sadly pronounced dead at the scene and we are still working to ensure their next of kin have all been informed, so understandably cannot say more at this time.
"We remain at the scene carrying out investigative work.
"Please avoid the area and find alternative routes where possible. We will update you when the motorway reopens."
There are long delays for anyone heading southbound on the M6 from Lancaster and the north and anyone heading on the M55 from Blackpool.
National Highways said: "Lancashire Police are at the scene and leading the incident.
"Expectations from the scene are that police will be conducting a collision investigation and the closure is expected to remain in place throughout the morning at least. "
The #M6 is closed southbound between J32 and J31 near #Preston following a serious collision. For more information, including the diversion route, please follow this link: https://t.co/oszhkj4m66 pic.twitter.com/MIFjrGJJqk
— National Highways: North-West (@HighwaysNWEST) September 4, 2022
Road users are advised to follow the solid square diversion symbols on road signs.
Exit M6 J32, Blackpool, onto M55. Exit M55 J1.
Broughton, take first roundabout exit, A6 Preston. At the A6/A5085 junction turn left (M6 South). Follow the A5085 to the A59 roundabout.
Take the first exit and follow the A59 to M6 J31, Tickle Trout. At the first roundabout take the second exit, M6 South, Birmingham.
At the second roundabout take the second exit, M6, The South, Birmingham.
Update to follow
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